Alexandra F Freeman Selected Research

Eczema

1/2021	STAT3 Hyper-IgE Syndrome-an Update and Unanswered Questions.
1/2020	The Child with Elevated IgE and Infection Susceptibility.
1/2019	An Update on Syndromes with a Hyper-IgE Phenotype.
1/2019	Insights into immunity from clinical and basic science studies of DOCK8 immunodeficiency syndrome.
9/2017	A biallelic mutation in IL6ST encoding the GP130 co-receptor causes immunodeficiency and craniosynostosis.
1/2017	DOCK 8 Deficiency, EBV+ Lymphomatoid Granulomatosis, and Intrafamilial Variation in Presentation.
1/2016	Hyper-IgE Syndromes and the Lung.
9/2015	Primary immunodeficiency update: Part II. Syndromes associated with mucocutaneous candidiasis and noninfectious cutaneous manifestations.
12/2013	Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation.
7/2013	Lung parenchyma surgery in autosomal dominant hyper-IgE syndrome.

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Alexandra F Freeman Research Topics

Disease

37	Job Syndrome (Hyper-IgE Syndrome) 01/2021 - 11/2005
36	Infections 01/2022 - 11/2005
18	Eczema 01/2021 - 11/2005
10	Reinfection 01/2019 - 11/2005
8	Eosinophilia 01/2022 - 11/2009
8	Primary Immunodeficiency Diseases 01/2020 - 05/2008
7	Hypersensitivity (Allergy) 01/2020 - 04/2008
7	Virus Diseases (Viral Diseases) 01/2019 - 11/2009
6	Dermatitis 01/2019 - 10/2006
5	Scoliosis 01/2021 - 11/2005
5	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2019 - 11/2010
5	Neoplasms (Cancer) 01/2017 - 03/2013
5	Pneumonia (Pneumonitis) 01/2016 - 10/2006
5	Chronic Granulomatous Disease 04/2015 - 11/2004
4	Inflammation (Inflammations) 01/2022 - 02/2010
4	Lymphopenia (Lymphocytopenia) 01/2021 - 01/2012
4	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2020 - 11/2004
4	Immune System Diseases (Immune Disorders) 01/2019 - 05/2013
4	Abscess 01/2018 - 12/2010
4	GATA2 Deficiency 01/2018 - 09/2011
4	Exanthema (Rash) 01/2012 - 11/2004
3	Pulmonary Alveolar Proteinosis 10/2021 - 02/2010
3	Wounds and Injuries (Trauma) 01/2021 - 02/2014
3	Food Hypersensitivity (Food Allergy) 01/2019 - 12/2013
3	Neutropenia 01/2019 - 12/2009
3	Bronchiectasis 09/2017 - 12/2008
3	Anaphylaxis (Anaphylactic Shock) 03/2017 - 12/2013
3	Mycoses (Diseases, Fungus) 01/2017 - 09/2015
2	Chronic Mucocutaneous Candidiasis 01/2022 - 04/2016
2	Necrosis 12/2020 - 04/2008
2	Autoimmune Diseases (Autoimmune Disease) 10/2020 - 02/2016
2	Viremia 10/2019 - 03/2012
2	Common Variable Immunodeficiency 01/2019 - 01/2012
2	Tuberculosis (Tuberculoses) 01/2019 - 01/2018
2	Lymphoma (Lymphomas) 01/2019 - 07/2014
2	Atopic Dermatitis (Atopic Eczema) 01/2019 - 12/2013
2	Immediate Hypersensitivity 01/2019 - 01/2016
2	Lung Abscess 05/2018 - 10/2006
2	Liver Abscess 01/2018 - 03/2012
2	Craniosynostoses (Craniosynostosis) 09/2017 - 03/2007
2	Warts (Wart) 01/2017 - 03/2012
2	Bacterial Infections (Bacterial Infection) 07/2013 - 05/2008
1	Vulvovaginal Candidiasis 01/2022
1	Candidiasis (Moniliasis) 01/2022
1	Thymoma (Thymic Carcinoma) 11/2021
1	Pulmonary Hypertension 10/2021
1	Hemorrhagic Cystitis 01/2021
1	Pure Red-Cell Aplasia 01/2021
1	Reticulocytosis 01/2021
1	Hematuria 01/2021
1	Osteoporosis 01/2021
1	Anemia 01/2021
1	Cicatrix (Scar) 01/2021
1	Keloid 01/2021
1	COVID-19 07/2020

Drug/Important Bio-Agent (IBA)

38	Immunoglobulin E (IgE)IBA 01/2022 - 11/2005
12	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2020 - 12/2008
8	Proteins (Proteins, Gene)FDA Link 01/2019 - 11/2010
5	AutoantibodiesIBA 10/2020 - 02/2010
4	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2020 - 09/2011
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2021 - 06/2017
3	ruxolitinibIBA 01/2021 - 01/2017
3	CytokinesIBA 12/2020 - 10/2007
3	Immunoglobulins (Immunoglobulin)IBA 05/2018 - 02/2010
3	Immunoglobulin M (IgM)IBA 08/2015 - 11/2009
2	Monoclonal AntibodiesIBA 01/2022 - 01/2021
2	Amphotericin B (Amphotericin)FDA LinkGeneric 01/2022 - 05/2007
2	BCG Vaccine FDA Link 12/2020 - 01/2018
2	Antiviral Agents (Antivirals)IBA 11/2020 - 01/2020
2	Pharmaceutical PreparationsIBA 01/2020 - 05/2018
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 02/2014
2	AntigensIBA 01/2019 - 04/2008
2	Interleukin-10 (Interleukin 10)IBA 12/2018 - 01/2018
2	Interleukin-6 (Interleukin 6)IBA 10/2018 - 10/2007
2	STAT1 Transcription FactorIBA 01/2018 - 04/2016
2	NADP (NADPH)IBA 01/2018 - 04/2015
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 04/2013 - 02/2010
2	DNA (Deoxyribonucleic Acid)IBA 03/2012 - 04/2011
2	Anti-Bacterial Agents (Antibiotics)IBA 03/2012 - 12/2010
1	AzolesIBA 01/2022
1	mRNA VaccinesIBA 11/2021
1	VaccinesIBA 11/2021
1	IronIBA 01/2021
1	daratumumabIBA 01/2021
1	Hemoglobins (Hemoglobin)IBA 01/2021
1	Hemagglutinins (Hemagglutinin)IBA 01/2021
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2021
1	MitogensIBA 01/2021
1	InterferonsIBA 01/2021
1	Immunosuppressive Agents (Immunosuppressants)IBA 01/2021
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	Immunomodulating AgentsIBA 07/2020
1	Vitamin D FDA LinkGeneric 07/2020
1	Complement System Proteins (Complement)IBA 07/2020
1	Busulfan (Busulfex)FDA Link 01/2020

Therapy/Procedure

15	Therapeutics 01/2022 - 11/2005
10	Hematopoietic Stem Cell Transplantation 10/2021 - 09/2011
6	Transplantation 01/2020 - 12/2009
3	Stem Cell Transplantation 10/2021 - 11/2004
2	Drug Therapy (Chemotherapy) 10/2016 - 12/2009